Adaptive design
Resources
Easy-to-read tutorial papers with case studies
There are some easy-to-read papers discussing the concept of adaptive designs and real-life case studies as well as general practical considerations:
- Pallmann et al. Adaptive designs in clinical trials: why use them, and how to run and report them. BMC Med. 2018;16:29.
- Burnett et al. Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs. BMC Med. 2020;18(1):352
- Park et al. Critical concepts in adaptive clinical trials. Clin Epidemiol. 2018;10:343–51.
- Thorlund et al. Key design considerations for adaptive clinical trials: A primer for clinicians. BMJ. 2018;p. k698
- Stallard et al. Efficient adaptive designs for clinical trials of interventions for COVID-19. Stat Biopharm Res. 2020;1–26.
- Porcher et al. Adaptive methods: when and how should they be used in clinical trials? Therapie. 2011;66:319–26.
Easy-to-read practical books with real-life case studies
These are some of non-technical and practical oriented books suitable for multidisciplinary audience. They also cover useful real-life case studies and considerations when using adaptive designs: